MEDICAL REFERENCES

Alpha Lipoic Acid

Increased ROS Generation and p53 Activation in Alpha Lipoic Acid-induced Apoptosis of Hepatoma Cells, Simbula, Columbano, Ledda, et al., Apoptosis 2007; 12 (1): 113-123.

 

Uptake, Recycling, and Antioxidant Actions of Alpha-lipoic acid in Endothelial Cells, Jones, Li, Qu, et al.,  Free Radic. Biol. Med. 2002; 33 (1): 83-93.

 

Alpha-Lipoic Acid Inhibits TNF-alpha Induced NF-kappa B Activation Through Blocking of MEKK1-MKK4-IKK Signalling Cascades, Lee, Lee, Kim, et al., Int. Immunopharmacol. 2008; 8 (2): 362-370.

 

Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Alpha Lipoic Acid in Human Lung Epithelial Cancer Cells Through Bcl-2 Down-regulation, Moungiaroen, Nimmannit, Callery, et al., J. Pharmacolo. Exp. 2006; 319 (3): 1062-1069.

 

R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase, Korotchkina, Sidhu,& Patel, Free Radic. Res. 2004; 38 (10): 1083-1092.

 

Alpha lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2* generation, Wenzel, Nickel & Daniel, Apoptosis 2005; 10 (2): 359-368.

 

Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cells through Bcl-2 down-regulation, Moungjaroen, Nimmannit, Callery, et al., J. Pharmacol. Exp. Ther. 2006; 319 (3): 1062-1069. Epub. 2006 Sept. 21.

 

Differential activity of lipoic acid enantiomers in cell culture, Smith, Thiagaraj, Seaver & Parker, J. Herb Pharmacother. 2005; 5 (3): 43-54.

Selective Inactivation of Alpha-ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-hydroxy-2-nonenal, Humphries & Szweda,  Biochemistry 1998; 37 (45): 15835-15841.

Interaction of Alpha-lipoic Acid Enantiomers and Homologues with the Enzyme Components of the Mammalian Pyruvate Dehydrogenase Complex, Löffelhardt, Bonaventura, Locher , et al.,  Biochem. Pharmacol. 1995; 50 (5): 637-646.

 

The Long-term Survival of a Patient with Pancreatic Cancer with Metastases to the Liver after Treatment with the Intravenous Alpha-Lipoic Acid/Low-dose Naltrexone Protocol, Berkson, Rubin & Berkson, Integr. Cancer Ther. 2006; 5 (1): 83-89.

 

Effective Treatment of Oxaliplatin-induced Cumulative Poly-neuropathy with Alpha-Lipoic Acid, Gedlicka, Scheithauer, Schull & Kornek, J. Clin. Oncol. 2002; 20 (5): 3359-3361.

Effects of Alpha Lipoic Acid on Transforming Growth Factor beta 1-p38 Mitogen-activated Protein Kinase-Fibronectin Pathway in Diabetic Nephropathy,Lee, Kang, Ryu, et al., Metabolism 2009; 58 (5): 616-623.

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