Oligomeric Proanthocyanidin Complexes: History, Structure & Phytopharmaceutical Applications, A. M. Fine.   Alt. Med Rev. 2000; Vol. 5, No. 2: 144-151. 

 

Cellular Protection with Proanthocyanidins Derived from Grape Seeds,  Bagchi, Bagchi & Stohs, et al, Ann. N. Y. Acad. Sci.  2002; 957: 260-270. 

 

Oligomeric Proanthocyanidins ( OPCs) – Monograph,  Alt. Med. Rev. 2003; Vol. 8, No.4: 442-450.

 

Chemoprevention of Colorectal Cancer by Grapeseed Proanthocyanidin is Accompanied by a Decrease in Proliferation and Increase in Apoptosis,   Nomoto, Iigo, Hamada, et al. Nutr. & Cancer. 2004; Vol. 49, No. 1: 81-89.

 

Alcohol and Polyphenolic Grape Extract Inhibit Platelet Adhesion in Flowing Blood, de Lange, Scholman, Kraaijenhagen, et al., Eur. J. Clin. Invest. 2004; 4 (12): 818-824.

 

Red Wine and Red Wine Polyphenolic Compounds But Not Alcohol Inhibit ADP-induced Platelet Aggregation, de Lange, van Golden, Scholman, et al., Eur. J. Intern. Med. 2003; 14 (6): 361-366.

 

Grape Seed and Skin Extracts Inhibit Platelet Function and Release of Reactive Oxygen Intermediates, Vitseva, Varghese, Chakrabarti, et al., J. Cardiovasc. Pharmacol. 2005; 46 (4): 445-451.

 

Proanthocyanidin from Grape Seeds Enhances Anti-tumor Effect of Doxorubicin Both in vitro & in vivo, Zhang, Bai, Wu, et al, Pharmazie, 2005; 60: 533-538.

 

Grape Seed Proanthocyanidin Extract Induced Mitochondria-associated Apoptosis in Human Acute Myeloid Leukaemia 14.3D10 Cells,  Hong & Qin,  Chin. Med. J. 2006; 119 (5): 417-421.

 

Grapeseed Extract Induces Apoptotic Death of Human Prostate Carcinoma DU145 Cells Via Caspases Activation Accompanied by Dissipation of Mitochondrial membrane Potential and Cytochrome C Release, Agarwal, Singh & Agarwal,   Carcinogenesis 2002; 23 (11): 1869-1876.

 

Suppression of Estrogen Biosynthesis by Procyanidin Dimers in Red Wine and Grape Seeds, Eng, Ye, Williams, et al., Cancer Res. 2003; 63 (23): 8516-8522.

 

Grapeseed Extract is an Aromatase Inhibitor and a Suppressor of Aromatase Expression,  Kijima, Phung, Hur, et al., Cancer Res. 2006; 66 (11): 5960-5967.

 

Grapeseed Extract Inhibits Advanced Human Prostate Cancer Growth and Angiogenesis and Upregulates Insulin-like Growth Factor Binding Protein 3, Singh, Tyagi, Dhanalakshmi, et al., Int. J. Cancer 2004; 108 (5): 733-740.

 

Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasis mutated-p53 activation, Kaur, Agarwal & Agarwal, Mol. Cancer Ther. 2006; 5 (5): 1265-1274.

 

Grape seed proanthocyanidin extract induced mitochondria-associated apoptosis in human acute myeloid leukaemia 14.3D10 cells, Hu & Qin, Chin. Med. J. 2006; 119 (5): 417-421.

 

Involvement of p21WAF1/Cip1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells, Kim, Lee, Choi, et al., Int. J. Oncol. 2003; 23 (4): 1143-1149. 

 

Proanthocyanidins from Grape Seeds Inhibit Expression of Matrix Metalloproteinases in Human Prostate Carcinoma Cells, Which is Associated with the Inhibition of Activation of MAPK and NF kappa B, Vayalil, Carcinogenesis 2004; 25 (6): 987-985.

 

Grape Seed Extract Inhibits Advanced Human Prostate Tumor Growth and Angiogenesis and Upregulates Insulin-like Growth Factor Binding Protein-3, Singh, Tyagi, Dhanalakshmi,   et al., Int. J. Cancer 2004; 108 (5): 733-740.

 

Grape Seed Extract Induces Apoptotic Death of Human Prostate Carcinoma DU145 Cells Via Caspases Activation Accompanied by Dissipation of Mitochondrial Membrane Potential and Cytochrome C Release, Agarwal, Singh & Agarwal, Carcinogenesis 2002; 23 (11): 1869-1876.

 

Inhibition of NF-kappaB Pathway in Grape Seed Extract-induced Apoptotic Death of Human Prostate Carcinoma DU145 Cells, Dhanalakshmi, Agarwal & Agarwal, Int. J. Oncol. 2003; 23 (3): 721-727.

 

Grape Seed Extract Inhibits EGF-induced and Constituitively Active Mitogenic Signallng but Activated JNK in Human Prostate Carcinoma DU145 Cells:Possible Role in Antiproliferation and Apoptosis, Tyagi, Agarwal & Agarwal, Oncogene 2003; 22 (9): 1302-1316.

 

Matrix Metalloproteinases in Cancer Metastasis: Molecular Targets for Prostate Cancer Prevention by Green Tea Polyphenols and Grape Seed Proanthocyanidins,Katiyar, Endocr. Metabol. Immune Disord. Drug Targets, 2006; 6 (1): 17-24.

 

Anti-cancer Activity of Grape and Grape Skin Extracts Alone and Combined with Green Tea Infusions, Morré & Morré, Cancer Lett. 2006; 238 (2): 202-209.

Gallic Acid, an Active Constituent of Grapeseed Extract, Exhibits Anti-proliferative, Por-apoptotic and Anti-tumorigenic Effects Against Prostate Carcinoma Xenograft Growth in Nude Mice, Kaur, Velmurugan, Rajamanickam, et al., Pharm. Res. 2009; June 20 [Epub ahead of print]  PMID: 19543955.

Grape Seed Extract Inhibits EGF-induced and Constitutively Active Mitogenic Signaling But Activates JNK in Human Prostate Carcinoma DU145 Cells: Possible Role in Anti-proliferation and Apoptosis, Tyagi, Agarwal & Agarwal, Oncogene 2003; 22 (9): 1302-1316.

 

Grape Seed Extract Inhibits in vitro and in vivo Growth of Human Colorectal Carcinoma Cells, Kaur, Singh, Gu, et al., Clin. Cancer Res. 2006; 12 (20 Pt 1): 6194-6202.

 

Proanthocyanidin from Grape Seeds Inactivates the PI3-kinase/PKB Pathway and Induces Apoptosis in aColon Cancer Cell Line, Engelbrecht, Mattheyse, Ellis, et al.,  Cancer Lett. 2007; 258 (1): 144-153.

 

Anti-angiogenic Efficacy of Grape Seed Extract in Endothelial Cells, Agarwal, Singh, Dhanalakshmi & Agarwal, Oncol. Rep. 2004; 11 (3): 681-685.

 

[Experimental Model for Treating Pulmonary Metastatic Melanoma Using Grape-seed Extract, Red wine and Ethanol], Martínez Conesa, Vicente Ortega, et al., Clin. Transl. Oncol. 2005; 7 (3): 115-121.

 

Grapeseed Extract Inhibits Angiogenesis via Suppression of the Vascular Endothelial Growth Factor Receptor Signaling Pathway, Wen, Lu, Zhang & Chen, Cancer Prev. Res. 2008; 1 (7): 554-561

 

Grapeseed Extract Inhibits VEGF Expression via Reducing HIF-1 alpha Protein Expression, Lu, Zhang, Chen & Wen, Carcinogenesis 2009; 30 (4): 636-644.

 

Proanthocyanidin from Grape Seeds Enhances Anti-tumor Effect of Doxorubicin both in vitro and in vivo,  Zhang, Bai, Wu, et al., Pharmazie 2005;60 (7): 533-538.

 

Synergistic Anti-cancer Effects of Grapeseed Extract and Conventional Cytotoxic Agent Doxorubicin Against Human Breast Carcinoma Cells, Sharma, Tyagi, Singh, et al., Breast Cancer Res. Treat. 2004; 85 (1): 1-12.

 

Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins,  Hou, Fujii, Terahara &Yoshimoto,  Biomed. Biotechnol. 2004; 2004 (5): 321-325

 

Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies, Aggarwal, Bhardwaj, Aggarwal, et al.,  Anticancer Res. 2004; 24 (5A): 2783-2840.

 

Resveratrol-induced Apoptosis in Human Breast Cancer Cells is Mediated Primarily Through the Caspase-3-dependent Pathway, Alkhalaf, El-Mowafy, Renno , et al., Arch. Med. Res. 2008; 39 (2): 162-168.  

 

Resveratrol Inhibits Proliferation, Induces Apoptosis, and Overcomes Chemo-resistance Through Down-regulation of STAT3 and Nuclear factor-kappaB-regulated Anti-apoptotic and Cell Survival Gene Products in Human Multiple Myeloma Cells, Bhardwaj, Sethi, Vadhan-Raj, et al., Blood 2007; 109 (6): 2293-2302.

 

Resveratrol Induces the Suppression of Tumor-derived CD4+CD25+ Regulatory T Cells,  Yang, Paik, Cho, et al., Int. Immunopharmacol. 2008; 8 (4): 542-547.

 

Resveratrol Induces Apoptosis and Differentiation in Acute Pro-myelocytic Leukemia (NB4) Cells, Cao, Wang, Liu, et al., J. Asian Nat. Prod. Res. 2005; 7 (4): 633-641. 

 

Resveratrol: A Candidate Nutritional Substance for Prostate Cancer Prevention, Stewart, Artime & O'Brian, J. Nutr. 2003; 133 (7 Suppl): 2440S-2443S.  

 

Resveratrol Inhibits Aggregation of Platelets from High-risk Cardiac Patients with Aspirin Resistance, Stef, Csiszar, Lerea, et al., J. Cardiovasc. Pharmacol. 2006; 48 (2): 1-5.