Indole-3-carbinol – Monograph, Alt. Med. Rev. 2005; Vol. 10 No. 4: 337-342.

 

Molecular Targets and Anticancer Potential of Indole-3-carbinol and Its Derivatives, Aggarwal & Ichikawa, Cell Cycle 2005; 4 (9): 1201-1215.

 

Changes in Levels of Urinary Estrogen Metabolite After Oral Indole-3-carbinol Treatment in Humans, Michnovicz, Adlercreutz & Bradlow, J. Natl. Cancer Inst. 1997; 89 (10): 718-723.

 

Indole-3-carbinol and Tamoxifen Cooperate to Arrest the Cell Cycle of MCF-7 Human Breast Cancer Cells, Cover, Hsieh, Cram, et al., Cancer Res. 1999; 59 (6):1244-1251.

 

Indole-3-carbinol and Prostate Cancer, Sarkar,  J. Nutr. 2004; 134 (12 Suppl): 3493S-3498S.

 

Indole-3-carbinol as a Chemopreventive and Anti-cancer Agent, Weng, Tsai, Kulp & Chen, Cancer Lett. 2008; 262 (2): 153-163.

 

Multiple Molecular Targets of Indole-3-carbinol, a Chemopreventative Anti-Estrogen in Breast Cancer, Ashtok, Chen, Garikapaty, et. al., Eur. J. Cancer Prev. 2002;  Suppl. 2: 86-93.

 

Placebo-controlled Trial of Indole-3-carbinol in the Treatment of CIN, Bell, Crowley-Nowick, Bradlow, et al., Gynecol. Oncol., 2000 Aug.; 78(2): 123-129.

 

Indole-3-carbinol and 3’-3’-Diindolylmethane Antiproliferative Signaling Pathways Control Cell-cycle Gene Transcription in Human Breast Cancer Cells by Regulating Promoter-Sp1 Transcription Factor Interactions, Firestone & Bjeldanes, J. Nutr. 2003; 133: 2448S-2455S.

 

Indole-3-carbinol Activates the ATM Signaling Pathway Independent of DNA Damage to Stabilize p53 and Induce G1 Arrest of Human Mammary Epithelial Cells.  Brew, Aronchik, Sheen, et al., Int. J. Cancer 2006 Feb 15; 118(4): 857-868.

 

BRCA1 and BRCA2 as Molecular Targets for Phytochemicals Indole-3-carbinol and Genistein in Breast and Prostate Cancer Cells.  Fan,  Meng, Auborn, et al.,  Br. J. Cancer 2006 Feb 13; 94(3): 407-426.

Gene Expression Profiling Revealed Survivin as a Target of 3,3'-Diindolylmethane-Induced Cell Growth Inhibition and Apoptosis in Breast Cancer Cells. Rahman,  Li,  Wang, et al.,  Cancer Res. 2006 May 1; 66(9): 4952-4960.

Indole-3-Carbinol (I3C) Inhibits Cyclin-dependent Kinase-2 Function in Human Breast Cancer Cells by Regulating the Size Distribution, Associated Cyclin E Forms, and Subcellular Localization of the CDK2 Protein Complex.  Garcia, Brar,  Nguyen, et al.,   J.  Biol. Chem.  2005 Mar. 11; Vol. 280, No. 10: 8756-8764.

Synthetic Dimer of Indole-3-carbinol: Second Generation Diet Derived Anti-Cancer Agent in Hormone Sensitive Prostate Cancer.  Garikapaty, Ashok, Tadi, et al.,  Prostate 2006 Apr 1; 66(5): 453-462.

Indole-3-carbinol (I3C) Induces Apoptosis in Tumorigenic but Not in Non-tumorigenic Breast Epithelial Cells, Rahman, Aranha, & Sarkar, Nutr. Cancer 2003; 45 (1): 101-112.

Translocation of Bax to Mitochondria Induces Apoptotic Cell Death in Indole-3-carbinol (I3C) Treated Breast Cancer Cells, Rahman, Aranha, Glazyrin, et al, Oncogene 2000; 19 (50): 5764-5771.

Indole-3-carbinol Enhances Ultraviolet-B-induced Apoptosis by Sensitizing Human Melanoma Cells, Kim, Jeong, Moon, et al., Cell. Mol. Life Sci. 2006; 63 (22): 2661-2668.

 

3,3’-Diindolylmethane is a Novel Mitochondrial H(+)-ATP Synthase Inhibitor That Can Induce p21(Cip1/Waf1) Expression by Induction of Oxidative Stress in Human Breast Cancer Cells,Gong, Sohn, Xue, et al., Cancer Res. 2006; 66 (9): 4880-4887.

 

Apoptosis-inducing Effect of Erlotinib is Potentiated by 3,3’-diindolylmethane in vitro and in vivo Using an Orthoptic Model of Pancreatic Cancer,  Ali, Banerjee, Ahmad, et al., Mol. Cancer Ther. 2008; 7 (6): 1708-1719.

Indole-3-carbinol and Prostate Cancer, Sarkhar & Li, J. Nutr. 2004; 134 (12Suppl.): 3493S-3498S.

 

Indole-3-carbinol Inhibition of Androgen Receptor Expression and Down-regulation of Androgen Responsiveness in Human Prostate Cancer Cells, Hsu, Zhang, Dev, et al., Carcinogenesis 2005;

 

Indole-3-carbinol (I3C) Induced Cell Growth Inhibition, G1 Cell Cycle Arrest and Apoptosis in Prostate Cancer Cells, Chinni, Li, Upadhyay, et al., Oncogene 2001;

 

Akt Inactivation is a Key Event in Indole-3-carbinol-induced Apoptosis in PC-3 Cells, Chinni & Sarkhar, Clin. Cancer Res. 2002; 8 (4): 1228-1236.

 

Anti-carcinogenic and Anti-metastatic Properties of Indole-3-carbinol in Prostate Cancer, Garikpaty, et al., Oncol. Rep.  2005; 13 (1): 89-93.

 

Indole-3-carbinol Induces a G1 Cell Cycle Arrest and Inhibits Prostate-specific Antigen Production in Human LNCaP Prostate Carcinoma Cells, Zhang, Hsu, Kinseth, et al., Cancer 2003; 98 (11): 2511-2520.

 

Selective Growth Regulatory and Pro-apoptotic Effects of DIM is Mediated by AKT and NF-kappaB Pathways in Prostate Cancer Cells, Li, Chinni & Sarkhar, Front. Biosci. 2005; 10: 236-243.

 

Indole-3-carbinol Prevents PTEN Loss in Cervical Cancer in vivo, Qi, Anderson, Chen, et al., Mol. Med. 2005; 11 (1-12): 59-63.

BRCA1 and BRCA2 as Molecular Targets for Phytochemicals Indole-3-carbinol and Genistein in Breast and Prostate Cancer Cells, Fan, Meng, Auborn, et al., Br. J. Cancer 2006; 94 (3): 407-426.

 

Molecular Targets and Anticancer Potential of Indole-3-carbinol and its Derivatives. Aggarwal & Ichikawa, Cell Cycle 2005; 4 (9): 1201-1215.