MEDICAL REFERENCES

Mitochondria

Mitochondria and Cancer, Jurasunas, Townsend Letter 2006; # 277/78: 83-86, 146-148.

 

A Mitochondria-K+ Channel Axis is Suppressed in Cancer and its Normalization Promotes Apoptosis & Inhibits Cancer Growth, Bonnet, Archer, Allalunis-Turner, et al., Cancer Cell 2007; 11 (1): 37-51. PubMed ID# 17222789

 

Restoration of Cellular Energetic Balance with L-Carnitine in the Neuro-bioenergetic Approach for Cancer Prevention and Treatment, Hoang, Shaw, Pham & Levine, Med. Hypotheses 2007; 69 (2): 262-272.

 

Increased Carnitine-dependent Fatty Acid Uptake into Mitochondria of Human Colon Cancer Cells Induces Apoptosis, Wenzel, Nickel & Daniel,J. Nutr. 2005; 135 (6): 1510-1514.

Carnitine Supplementation Alleviates Cancer-Related Fatigue, Cruciani, et al., J. Pain Sympt. Man. 2006; 32: 551-559.

 

Voltage-Dependent Anion Channel (VDAC) as Mitochondrial Governator – Thinking Outside the Box, Lemasters & Holmuhamedov, Biochem.Biophys. Acta 2006; 1762 (2): 181-190.

 

Lactate: mirror and motor of tumor malignancy, Walenta & Mueller-Klieser ,Semin Radiat Oncol. 2004; 14 (3): 267-74.

 

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers, Walenta, Wetterling, Lehrke, et al., Cancer Res. 2000; 60 (4): 916-921.

 

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression, Gottfried, Kunz-Schughart, Ebner, et al., Blood. 2006; 107 (5): 2013-2021.

 

Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group, Koukourakis, Giatromanolaki, Sivridis, et al., J Clin Oncol. 2006; 24 (26): 4301-4308. Epub 2006 Aug 8.

 

Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer, Koukourakis, Giatromanolaki, Simopoulos, et al., Clin Exp Metastasis 2005; 22( 1): 25-30.

 

Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity,  Newell, Franchi, Pouysségur & Tannock,  Proc Natl Acad Sci U S A. 1993; 90 (3): 1127-1131.

 

Early and Late Apoptosis Events in Human Transformed and Non-transformed Colonocytes are Independent of Intracellular Acidification,  Wenzel& Daniel, Cell Physiol Biochem. 2004;14 (1-2): 65-76.

 

Mitochondria and cancer: Warburg addressed, Wallace, Cold Spring Harb. Symp. Quant. Biol. 2005; 70: 363-374.

Cu2+ toxicity inhibition of mitochondrial dehydrogenases in vitro and in vivo, Sheline & Choi, Ann. Neurol. 2004; 55 (5): 645-653.

Cofactors of mitochondrial enzymes attenuate copper-induced death in vitro and in vivo, Sheline, Choi, Kim-Han, et al.,  Ann Neurol.  2002; 52 (2): 195-204.

 

The biological significance of cancer: mitochondria as a cause of cancer and the inhibition of glycolysis with citrate as a cancer treatment,  Halabe Bucay, Med Hypotheses  2007; 69( 4): 826-828.

 

Cheap, safe drug kills most cancers, Coghlan, New Scientist January 2007.

Effect of thiamine phosphates on the activity of regulatory enzymes of the pyruvate dehydrogenase complex,  Parkhomenko, Chernysh, Cjurilova, et. al., Ukr. Biokhim. Zh. 1987; 59 (5): 49-54.

 

Bovine heart pyruvate dehydrogenase kinase stimulation by alpha-ketoisovalerate, Robertson, Barron & Olson, J. Biol. Chem.  1990; 265 (28): 16814-16820.

 

Co-enzyme Q10 improves lactic acidosis, stroke-like episodes and epilepsy in a patient with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes), Berbel-Gacia, Barbera-Farre, Etessam, et al., Clin. Neuropharmacol. 2004; 27 (4): 187-191.

 

Mitochondria Rescue (Possibly) Heals Cancer? , McKinney, Naturopathic Doctor News & Review - May 2008; 4 (5): 10-11.

Antioxidants &
Artemisinin
Ashwagandha
Avemar
Boswellia
Breast Cancer
Butyrate
Chinese Medicine (TCM)
Co-enzyme Q10
Curcumin &
Diet & General Integrative
Ginger
Grape Seed Extract &
Green Tea EGCG &
Indole-3-Carbinol
Alkylglycerols
(Withania)
Alpha Lipoic Acid
Herbs & Acupuncture
Resveratrol
Chemotherapy
Inflammation
Oncology  (Miscellany)
Polyphenols
Melatonin
Milk Thistle
Mistletoe Lectins
Mitochondria
Modified Citrus Pectin
Mushrooms (Reishi,
Omega 3 Oils
Phytoestrogens & Soy
Pomegranate &
Prevention
Quercitin
Radiation
Bibliography
Recommended
Web Resources
Journals
Stem Cells & Immune Cells
Button Mushrooms, etc.)
Ellagic Acid
Sugar, Insulin & IGF
Surgery
Vitamin C
Vitamin D
Vitamin K
Low-Dose
Naltrexone